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GLP-1R modulator C16 is a small-molecule allosteric modulator that enhances GLP-1 binding to the GLP-1 receptor via a transmembrane site (CAS 875005-43-9). It is characterized in vitro with an EC50 of 8.43 ± 3.82 μM, a molecular weight of 408.89 g·mol⁻1, and high chemical purity suitable for research applications.
Allosteric modulator of GLP-1 receptor activity.
Characterized potency (EC50 8.43 ± 3.82 μM) for in vitro studies.
High chemical purity (99.6%) for reproducible results.
Compact quantities suitable for early-stage pharmacology.
Useful for studying GLP-1R pharmacology and GPCR signaling.
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Sulindac(MK-231) is a non-steroidal COX inhibitor which potently inhibits prostaglandin synthesis used in the treatment of acute or chronic inflammatory conditions
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Sulindac sulfide is a noncompetitive γ-secretase inhibitor, with an IC50 of 20.2 μM for γ42-secretase activity. For research use only. MedChemExpress does not sell to patients.
Solubility in vitro: DMSO at 50 mg/mL (146.88 mM), requires ultrasonic assistance, use newly opened DMSO due to hygroscopic nature.
Stock solution storage: -80°C for 6 months; -20°C for 1 month.
Shipping: Room temperature in continental US; may vary elsewhere.
Storage of powder: -20°C for 3 years; in solvent: -80°C for 6 months, -20°C for 1 month.
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An NSAID, a COX-2 inhibitor (IC50 = 0.79 µM), and a prodrug form of sulindac sulfide; selective for COX-2 over COX-1 (IC50 = >1,000 µM); inhibits acetic acid-induced writhing in mice and reduces carrageenan-induced paw edema in rats at 100 mg/kg; reduces tumor growth in a BxPC-3 mouse xenograft model at 60 mg/kg
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Sulforaphane is a research-grade isothiocyanate that activates the Keap1/Nrf2/ARE antioxidant pathway and inhibits histone deacetylases. Supplied as a high-purity powder, it is intended for use in in vitro and in vivo studies of antioxidant response, anticancer activity, and anti-inflammatory mechanisms.
High purity: 98.9%.
CAS number: 4478-93-7.
Molecular formula: C6H11NOS2; MW: 177.29 g/mol.
Suitable for in vitro and in vivo applications.
Storage: powder -20°C; in solvent -80°C for long-term storage.
Available in small research quantities, including 5 mg.
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GPR120 modulator 1 is a G protein coupled receptor 120 (GPR120) modulator. This compound, extracted from patent US8394841B2 (compound example F1), is suitable for research into diseases linked to abnormal or deregulated GPR120, including diabetes.
Modulates G protein coupled receptor 120 (GPR120)
Supports research on diseases linked to GPR120 deregulation, such as diabetes
Purity of 98.1% (HPLC)
White to off-white solid appearance
Chemical formula C19H16ClNO4S
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